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President Shi 
President Shi

CURRICULUM VITAE

JINGSHAN SHI, M.D., Ph.D.

PRESIDENT, DIRECTOR

PERSONAL INFORMATION:

Date of Birth:04/27/59

Address:Zunyi Medical University

201 Dalian Road, Zunyi, Guizhou 563003

P. R. China

Telephone:

Home:86-852- 8625886

Office:86-852-8609788

E-Mail:shijs@zmc.edu.cn

EDUCATION:

1996 Ph.D., Pharmacology, Fudan University, Shanghai, China

1989 Master of Science, Pharmacology, Zunyi Medical University, Guizhou, China

1982 M.D., Medicine, Zunyi Medical University, Guizhou, China

CURRENT POSITION:

2005-Present President

2002-2005 Vice-president

2000-2001 Director of the Graduates Section

1999-2000 Associate Director of Section of Basic Medicine Zunyi Medical University, Zunyi, China

1998-Present Professor of Pharmacology, Department of Pharmacology

1996-1998 Associate Director, Department of Pharmacology Zunyi Medical University, Zunyi, China

PROFESSIONAL EXPERIENCE:

02/99-03/00 Senior Visiting Scholar

Department of Anatomy & Cell Biology, Institute of Neuroscience, Goteborg University,Sweden

*Apoptosis research in rat brain, neurons (differentiated from NT2 cell line) and NT2 cell line: Tenul staining; determination of cell visibility; DNA ladder electrophoresis; expression of relative protein by Western blotting.

*Isolation and purification of neuronspecific enolase in human brain.

*Culture and differentiation of cell line (NT2) and micro- transplant of neuron in rat brain.

*Immunohistochemistry of c-fos, c-jun, amyloid precursor protein in trauma modelof rats.

*microdialysis on rat & rabbit brain.

08/97-01/99 Associate Professor and Professor

Department of Pharmacology, Zunyi Medical University Zunyi, China

*Pharmacological characterization of anti-hypertensive drug screened with recombinant carboxyesterase which were expressed in insect Sf9-cell

*Isolate, purify and analyze the active metabolites of two antihypertensive drug (KT-611 & isorhynchophylline) in animal.

*Determine the effect of Isocorydine on calcium transport in myocardial cell and vascular smooth muscle cell (radio and Fura-2 label).

*Compare cAMP and cGMP in cultured vascular smooth muscle cells, and the effect of vasodilators.

*As director of 6 graduated students in cardiovascular pharmacology & neuropharmacology researchfield.

09/93-07/97 Graduate Student for Ph.D. Program

Department of Pharmacology Shanghai Medical University, Shanghai, China

*Pharmacodynamic & pharmacokinetic studies of thrombolytic elements in earthworm.

*Alteration of free calcium of vascular smooth muscle cells in atherosclerosis model.

*Analysis of 2114 peptide in animal plasma and tissues, and its effect of free radical.

01/83-08/93 Assistant Professor

Graduate Student for Master Degree of Pharmacology,Department of Pharmacology, Zunyi Medical University Zunyi, China

*Cardiovascular effects of Rhynchophlline and Isorhynchophylline in conscious and anesthetized animals.

*Effect of Rhynchophylline and Isorhynchophylline on the transmitters in CNS.

*Pharmacokinetics of Isorhynchophylline in animals.

GRANTS (As Principal Investigator):

05/11-12/14 “973” Pre-foundation

01/10-12/12 Fund of National Natural Science, National Natural Scientific Foundation, China

01/01-12/09 Fund of National Natural Science, National Natural Scientific Foundation, China

01/99-12/01 Fund of National Natural Science, National Natural Scientific Foundation, China

03/98-01/00 Scientific Fund of Guizhou Province, China

01/97-12/98 Training Fund of Youth Scientist for 21st Century, Guizhou Province, China

01/95-12/97 Youth Scientific Fund of National Public Health, Ministry of Public Health,China

01/94-12/95 Scientific Fund of Guizhou Province, China

01/92-12/93 Scientific Fund of Guizhou Province, China

HONORS:

Training candidate of youth scientist for 21st century, Guizhou Province 1997

Scientific and Technological Achievement Award in Health Science, Guizhou Province 1997

Scientific Progress Award of Guizhou Province 1993

Scientific Progress Award of Guizhou Province 2002

Scientific Progress Award of Guizhou Province (2001 J-3-15-2)

Scientific Progress Award of Guizhou Province (2004 J-2-3-1)

Scientific Progress Award of Guizhou Province (2008 J-3-21-2)

Scientific Progress Award of Guizhou Province (2009 J-2-1-1)

Scientific Progress Award of Guizhou Province (2011 J-1-2-1)

PEER REVIEWED PUBLICATIONS (Selected in English, as Correspondence)

1. Fei Li, Qihai Gong, Hongxin Dong and Jingshan Shi*. Resveratrol, A europrotective Supplement for Alzheimer’s Disease. Current Pharmaceutical Design, 2012, 18, 7-33

2. Lu YF, Wu Q, Liang SX, Miao JW, Shi JS, Liu J.Evaluation of hepatotoxicity otential of Cinnabar-containing An-Gong-Niu-Huang Wan, a patent traditional Chinese edicine. Regul Toxicol Pharmacol. 2011 Mar 21. [Epub ahead of print]

3. Wu Q, Lu YF, Shi JZ, Liang SX, Shi JS, Liu J.Chemical form of metals in traditional medicines underlines potential toxicity in cell cultures.J Ethnopharmacol. 2011 Feb 1. [Epub ahead of print]

4. Lu YF, Yan JW, Wu Q, Shi JZ, Liu J, Shi JS*. Realgar- and cinnabar-containing an-gong-niu-huang wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride. Chem Biol Interact. 2011 Jan 15;189(1-2):134-40.

5. Lu YF, Wu Q, Yan JW, Shi JZ, Liu J, Shi JS*.Realgar, cinnabar and n-Gong-Niu-Huang Wan are much less chronically nephrotoxic than common arsenicals and mercurials. Exp Biol Med (Maywood). 2011 Feb;236(2):233-9.

6. Liu J, Liang SX, Lu YF, Miao JW, Wu Q, Shi JS*. Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate.J Ethnopharmacol. 2011 Mar 8;134(1):26-31.

7. Guo J, Li F, Wu Q, Gong Q, Lu Y, Shi J*. Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. Phytomedicine. 2010;17(12): 950-955 .

8. Gong QH, Li F, Jin F, Shi JS*. Resveratrol attenuates neuroinflammation mediated cognitive deficits in rats. Journal of Health Science. 2010; 56(6):655-663.

9. Li Y, Li F, Gong Q, Wu Q, Shi JS*. Inhibitory Effects of Dendrobium Alkaloids on Memory Impairment Induced by Lipopolysaccharide in Rats. Planta Med. 2010; 76:1-5.

10. Li F Gong QH, Wu Q, Lu YF, Shi JS*. Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats. Pharmacol Biochem Behav.2010;96(3):301-305.

11. Zhang F, Shi JS, Zhou H, Wilson B, Hong JS, Gao HM. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol. 2010 Sep 1;78(3):466-77.

12. Zhang F, Liu J, Shi JS*. Anti-inflammatory activities of resveratrol in the brain: role of r esveratrol in microglial activation. Eur J Pharmacol. 2010 Jun 25;636(1-3):1-7.

13. Zhang F, Qian L, Flood PM, Shi JS, Hong JS, Gao HM. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J Pharmacol Exp Ther. 2010,333:822-33.

14. Wang Q, Gong Q, Wu Q, Shi JS*. Neuroprotective effects of Dendrobium alkaloids on rat cortical neurons injured by oxygen-glucose deprivation and reperfusion. Phytomedicine. 2010;17(2):108-15.

15. Nie J, Luo Y, Huang XN, Gong QH, Wu Q, Shi JS*. Icariin inhibits beta-amyloid peptide segment 25-35 induced expression of beta-secretase in rat hippocampus. Eur J Pharmacol. 2010;626(2-3):213-8.

16. Xu RX, Wu Q, Luo Y, Gong QH, Yu LM, Huang XN, Sun AS, Shi JS*. Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats. Clin Exp Pharmacol Physiol. 2009;36(8):810-5.

17. Jin F, Wu Q, Lu YF, Gong QH, Shi JS*. Neuroprotective effect of resveratrol on 6-OHDA induced Parkinson's disease in rats. Eur J Pharmacol. 2008;600(1-3): 78-82.

18. Gong QH, Wang Q, Shi JS Huang XN*Liu Q*Ma H. Inhibition of caspases and the intracellular free Ca2+ concentration are involved in resveratrol protection against apoptosis in rat primary neuron cultures. Acta Pharmacologica Sinica. 2007; 28 (11): 1724-1730.

19. Chen XP, Xun KL, Wu Q, Zhang TT, Shi JS, Du GH. Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: Role of reactive oxygen species. Vascular pharmacology.2007,47(1):1-9.

20. Luo Y, Nie J, Gong QH, Lu YF, Wu Q, Shi JS*. Protective effects of icariin against learning and memory deficits induced by aluminium in rats. Clin Exp Pharmacol Physiol. 2007:34(8):792-5.

21. Jiang QS, Huang XN, Dai ZK, Yang GZ, Zhou QX, Shi JS, Wu Qin.Inhibitory effect of ginsenoside Rb-1 on cardiac hypertrophy induced by monocrotaline in rat. Journal of Ethnopharmacology.2007, 111(3): 567-572.

22. Li L, Zhou QX Shi JS*. Protective effects of icariin on neurons injured by cerebral ischemia/reperfusion. Chin Med J. 2005;118(19):1637-43.

23. Gong QH, Wu Q, Huang XN, Sun AS, Shi JS*. Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats. Life Sci. 2005; 77 (2) :140-148.

24. Shi JS, Yu JX, Chen XP, Xu RX.Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacologica Sinica.2003,24(2): 97-101.

25. Luo C, Wu Q, Huang XN, Sun AS, Shi JS*.Ginkgo biloba leaf extract enhances levels of caspase-3 and amyloid precursor protein in normal rat hippocampus. Acta Pharmacologica Sinica. 2003,24(2): 152-156.

26. Säljö A, Bao F, Jingshan S, Hamberger A, Hansson HA, Haglid KG. Exposure to short-lasting impulse noise causes neuronal c-Jun expression and induction of apoptosis in the adult rat brain. Journal of Neurotrauma. 2002,19(8): 985-991.

27. Shi JS, Kenneth HG.Effect of rhynchophylline on apoptosis induced by dopamine in NT2

cells. Acta Pharmacologica Sinica. 2002,23(5): 445-449.

28. Säljö A, Bao F, Shi J, Hamberger A, Hansson HA, Haglid KG.Expression of c-Fos and

c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise. Journal of neurotrauma.2002,19(3): 379-385.

29. Yang SF, Wu Q, Sun AS, Huang XN, Shi JS*.Protective effect and mechanism of Ginkgo biloba leaf extracts for Parkinson disease induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Acta Pharmacologica Sinica.2001, 22(12): 1089-1093.

30. Runnerstam M, Bao F, Huang Y, Shi J, Gutierrez E, Hamberger A, Hansson HA, Viano D,Haglid K A new model for diffuse brain injury by rotational acceleration: II. Effects on extracellular glutamate, intracranial pressure, and neuronal apoptosis. J Neurotrauma.2001,18(3):259-73.

31. Shi JS, Huang B, Wu Q, Ren RX, Xie XL. Effects of rhynchophylline on motor activity of mice and serotonin and dopamine in rat brain. Acta Pharmacologica Sinica.1993,14(2): 114-117.

32. Shi JS, Liu GX, Wu Q, Huang YP, Zhang XD. Effects of Rhynchophylline and Isorhynchophylline on Blood Pressure and Blood Flow of Organs in Anesthetized Dogs. Acta Pharmacologica Sinica.1992,13(1): 35-38.

33. Jin F, Jin H, Wu Q, Zhang F, Lu YF, Gong QH, Shi JS*.Resveratrol prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide.Basic Clinical Pharmacology Toxicology.(16th World Congress on Basic and Clinical Pharmacology, 17-23 July,2010,Copenhagen,Denmark)

34. Wu Q, Deng J, Huang XN, Shi JS*. Protective effect of rutaecarpine against myocardial hypertrophy in rats. Basic Clinical Pharmacology Toxicology.(16th World Congress on Basic and Clinical Pharmacology, 17-23 July,2010,Copenhagen,Denmark)

35. Xie XL, Wu M, WU Q,Huang XN,Gong QH, SHI JS*. Effect of Rhynchophylline on platelet aggregation and cytoplasmic free calcium level in rabbit platelets. Basic Clinical Pharmacology Toxicology.(16th World Congress on Basic and Clinical Pharmacology,17-23 July,2010,Copenhagen,Denmark)

36. Li YF, Li F, Gong QH, Wu Q, SHI JS*. Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats. Basic Clinical Pharmacology Toxicology. (16th World Congress on Basic and Clinical Pharmacology, 17-23 July,2010,Copenhagen,Denmark)

37. Li F, Gong QH, Wu Q, Lu YF, Shi JS*. Icariin attenuates learning and memory deficits induced by D-galactose in rats. Basic& Clinical Pharmacology Toxicology.(16th World Congress on Basic and Clinical Pharmacology, 17-23 July,2010,Copenhagen,Denmark)

38. Yang S, Li F, Gong QH, Wu Q, Lu YF, Shi JS*. Reflection of Dendrobium Nobile Lindl. Alkaloids on lipopolysaccharide induced tau protein hyperphosphorylation in the hippocampus of rats. Basic& Clinical Pharmacology& Toxicology.(16th World Congress on Basic and Clinical Pharmacology, 17-23 July,2010,Copenhagen,Denmark)

39. Liu C, Wu Q, Lu YF, Gong QH, Shi JS*. Pharmacokinetics of Dendrobine, an alkaloid from Dendrobium Nobile, in rats. Basic & Clinical Pharmacology & Toxicology.(16th World Congress on Basic and Clinical Pharmacology, 17-23 July,2010,Copenhagen,Denmark)

40. Huang Q, Wu Q, Yu LM, Shi JS*. Protective effects of Dendrobium Nobile Lindl. alkaloids,in enrich-diet and streptozotocin induced diabetes rats.. Journal of Pharmacological Sciences.2009.Suppl.1,109: 195P-195P. (82nd Annual Meeting of the Japanese Pharmacological Society, MAR 16-18, 2009Yokohama,JAPAN)

41. Wang LY, Huang B, Shi JS*. Effects of Dendrobium polysaccharides on the learning and memory deficits and resisting senility in aging mice induced by D-galactose. Journal of Pharmacological Sciences. 2009.Suppl.1,109:248P-248P. (82nd Annual Meeting of the Japanese-Pharmacological-Society, MAR 16-18, 2009Yokohama,JAPAN)

42. Guo JX, Gong QH, Shi JS. *, Protective effect of icariin on brain dysfunction induced by lipopolysaccharide in rat model, Acta Pharmacologica Sinica,2006 July ;Supplement 1:102.(Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006,Beijing,China)

43. Jin F, Wen GR, Shi JS*. Protective effects of resveratrol on rat model with Parkinson’s disease induced by 6-OHDA, Acta Pharmacologica Sinica,2006 July ;Supplement 1:102.(Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006,Beijing,China)

44. Wang Q, Gong QH, Wu Q, Shi JS*.Protective effects of Dendrobium alkaloid in the Nerve Cell Injured by Ischemia/Reperfusion, Acta Pharmacologica Sinica, 2006,Supplement 1:103.(Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006, Beijing,China)

45. Li YJ, Sun AS*, Huang XN, Shi JS. Effects of evodiamine and rhynchophylline on Angiotensin *-induced Proliferation inrat Vascular Smooth Muscle Cells. Acta Pharmacologica Sinica,2006,Supplement 1:154. (Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006,Beijing,China)

46. Wu M, Huang XN, Wu Q, Shi JS, Xie XL*, Inhibitory effects of isorhynchophy on platelet aggregation and thrombosis. Acta Pharmacologica Sinica,2006,Supplement 1:155. (Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006,Beijing,China)

47. Chen XP, Wu Q, Zhang TT, Shi JS, Du GH*. Oxidized low density lipoprotein induces apoptosis in human umbilical vein endothelial cell:potential role of reactive oxygen species.Acta Pharmacologica Sinica,2006,Supplement 1:167. (Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006,Beijing,China)

48. Wang YT, Huang XN*, Sun AS, Shi JS. Antihypertrophic effect of ginsenoside Rg1 on cardic myocytes and its mechanisms. Acta Pharmacologica Sinica,2006,Supplement 1:126.(Abstracts of the 15th World Congress of Pharmacology, July 2-7,2006,Beijing,China)

49. GONG Qi-Hai, HUANG Bin, SHI Jing-Shan*. Ginkgo biloba leaf extract attenuates learning and memory deficit induce by bradykinin and ies mechanisms in rats, Chin J Pharmacol Toxicol,2007 Aug;21(4):314.( The 3rd Pharmacology and Clinical Pharmacology of China and Japan,July,2007,Dalian, China)

50. JIN Feng, GONG Qi-Hai, LU Yuan-Fu, WU Qin, SHI Jing-Shan*. protective effect of resveratrol on rat model with Parkinson’s disease induced by 6-OHDA and its mechanisms. Chin J Pharmacol Toxicol,2007 Aug;21(4):322.( The 3rd Pharmacology and Clinical Pharmacology ofChinaandJapan,July,2007,Dalian,China)

51. NIE Jing,LUO Yong, GONG Qi-Hai,SHI Jing-Shan*. Icariin inhibirs experession of β-secretase mRNA induce by A*25-35 Chin J Pharmacol Toxicol, 2007 Aug; 21(4):332.( The 3rd Pharmacology and Clinical Pharmacology of China andJapan,July,2007,Dalian,China)

52. DENG Jiang, Wu Qin, HUANG Xie-Nan*, SHI Jing-Shan.protective effect of ligustrazine on left ventricular hypertrophy induce by aorta coarctation in rats, Chin J Pharmacol Toxicol,2007 Aug;21(4):311.( The 3rd Pharmacology and Clinical Pharmacology of China and Japan,July,2007,Dalian, China)

53. XIE Xiao-Long*, WU Qi, HUANG Xie-Nan, GONG Qi-Hai, SHI Jing-Shan.effect of isorhynchophylline on platelet aggregation and cytoplasmic free calcium level in rabbit

platelets, Chin J Pharmacol Toxicol,2007 Aug;21(4):336.( The 3rd Pharmacology and Clinical Pharmacology ofChinaandJapan,July,2007,Dalian,China)

54. Zhang F Liu J Shi JS*. An-Gong-Niu-Huang Wan and Realgar in protection against LPS-induced neurotoxicity in rat primary neuron-glial cultures. Chinese Journal of Pharmacology and Toxicology 2010,24 (3):161-167

55. Gong QH, Wu Q, Huang XN, Sun AS, Nie J, Shi JS*. Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats. Chin J Integr Med. 2006;12(1):37-41.

56. Yang SF, Wu ZJ, Yang ZQ, Wu Q, Gong QH, Zhou QX, Shi JS*. Protective effect of ecdysterone on PC12 cells cytotoxicity induced by beta-amyloid25-35. Chin J Integr Med. 2005;11(4):293-6.

57. Li L, Zhou QX, Shi JS*. Protective effects of icariin on neurons injured by cerebral ischemia/reperfusion. Chin Med J. 2005;118(19):1637-43.

58. Li B, Wu Q, Shi JS, Sun AS, Huang XN. Effects of protopine on intracellular calcium and the PKC activity of rat aorta smooth muscle. Acta physiologica sinica. 2005;57(2):240-6.

59. Jiang QS, Huang XN, Yang GZ, Dai ZK, Zhou QX, Shi JS, Wu Q.Cardiac hypertrophy induced by prostaglandin F(2alpha) may be mediated by calcineurin signal transduction pathway in rats.Acta Physiologica Sinica.2005,57(6):742-8.

60. Yang SF, Yang ZQ, Zhou QX, Wu Q, Huang XN, Shi JS*. Effect of ecdysterone on the expression of c-fos in the brain of rats induced by microinjection beta-AP25-35 into the hippocampus. Acta Pharmaceutica Sinica. 2004;39 (4): 241-4.

61. Lu YF, Xie XL, Wu Q, Wen GR, Yang SF, Shi JS*. Effects of rhynchophylline onmomomine transmitter contents of striatum and hippocampus in cerebral ischemic rats. Chin J Pharmacol Toxicol. 2004;18(4):253-8.

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